急性白血病患者血脂、β2-微球蛋白及肿瘤坏死因子α水平测定的临床意义

Clinical value of blood lipid, serumβ2-microglolulin and tumor necrosis factor-α level in patients with acute leukemia

    摘要
  • 摘要:
    目的 探讨血脂、β2-微球蛋白（β2-MG）和肿瘤坏死因子α（TNF-α）对急性白血病诊断的临床意义。
    方法 采用放射免疫分析法测定血清中β2-MG和TNF-α的水平，生化法进行血脂分析，进行相关性检验。
    结果 123例急性白血病患者中包括46例急性单核细胞白血病、32例急性淋巴细胞白血病和45例急性非淋巴细胞白血病。患者血脂、血清β2-MG和TNF-α水平与36名正常对照者比较：三酰基甘油、β2-MG和TNF-α均增高（t=4.123~6.815, P均 < 0.01），血清脂蛋白（α）轻度增高但无明显差异（t=1.345，t=1.421, t=1.381, P > 0.05），胆固醇、高密度脂蛋白-胆固醇、低密度脂蛋白-胆固醇、载脂蛋白A均降低（t=2.110~2.574, P < 0.05），载脂蛋白B轻度降低但无明显差异（t= 1.261, t=1.381, t=1.456, P > 0.05）。
    结论 急性白血病的血脂、血清β2-MG和TNF-α水平的测定有助于疾病的诊断。

     

    Abstract:
    Objective To study on diagnosis value of blood lipid, serum β2-microglolulin(β2-MG)and tumor necrosis factor-α(TNF-α)in acute leukemia.
    Methods The serum β2-MG and TNF-α(with radioimmunoassay)blood lipid(with biochemistry)levels were determined in 123 patients with acute leukemia as well as 36 controls, then conducted the correlative tests.
    Results Serum β2-MG、TNF-α and triglyceride levels in 123 patients including 46 patients with acute monocytic leukemia, 32 patients with acute lymphocytic leukemia and 45 patients with acute nonlymphocytic leukemia were significantly higher than those in 36 controls(t=4.123-6.815, P < 0.01).The serum lipoprotein(α)level was tightly increased(t=1.345, t=1.421, t=1.381, P > 0.05); The serum cholesterol, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, apolipoprotein A levels in 123 patients with acute leukemia were significantly lower than those in 36 controls(t=2.110-2.574, P < 0.05), the serum apolipoprotein B level was tightly lowed(t=1.261, t=1.381, t=1.456, P > 0.05).
    Conclusion The determination of blood lipid, serum β2-MG and TNF-α level might be useful for diagnosing acute leukemia and reflecting the prognostic value.

     

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