Abstract: Malignant tumors presented with bone metastasis.Earlier detection of bone metastasis can prevent skeletal-related events and improve prognosis.Common radiopharmaceuticals for bone metastasis include ⁸⁹Sr, ¹⁵³Sm, ¹⁸⁶Re/¹⁸⁸Re, ¹¹⁷Sn and ³²P, the effectiveness of them is identified, especially for osteoplastic metastasis and mixed metastasis.Radiopharmaceuticals combined with bisphosphonates for extensive painful bone metastasis is significantly more effective than using either of them alone, in improving the life quality of cancer patients.