Abstract: Tumor angiogenesis is the foundation of tumor growth and metastasis.The vascular endothelial growth factor(VEGF)and VEGF receptor(VEGFR)plays a pivotal role in regulating tumor angiogenesis.VEGFR has become a common molecular target which has a potential value in angiogenesis diagnosis and therapy at present.Radionuclide receptor imaging has the advantage of high sensitivity and specificity, by which distribution density of VEGFR and its affinity with its ligand in tumor tissue can be revealed.VEGFR imaging is helpful in diagnosis, staging and detection of recurrence and metastasis of tumor and plays an instructive role in biological therapy of tumor mediated by VEGFR.