甲亢患者尿β2-微球蛋白、白蛋白、免疫球蛋白G联检及临床分析

Joint detection and clinical analyse of urine β2-microglobulin,albumin and immunoglobulin G in patients with hyperthyroidism

    摘要
  • 摘要: 目的 评价尿β2-微球蛋白(β2-MG)、白蛋白(Alb)、免疫球蛋白G(IgG)联检在甲亢患者中的临床意义。方法 放免法检测120例甲亢患者和45名健康体检者尿β2-MG、Alb、IgG和血清游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)水平,对各参数进行对比分析。结果 尿β2-MG、Alb、IgG水平在甲亢A(原发组)组与B组(未治愈组)中明显高于对照组及甲亢C组治愈组(t=6.682,P<0.01);甲亢B组又高于甲亢A组(t=2.385,P<0.05);甲亢C组与对照组无显着性差异(t=0.568,P>0.05)。甲亢组尿β2-MG、Alb、IgG分别与血清FT3、FT4水平具有较好的相关性,相关系数分别为0.98、0.88、0.93、0.87、0.94、0.85。结论 联合检测尿β2-MG、Alb、IgG对于早期发现甲亢患者肾功能损害、确定肾脏受损部位及肾小球损伤的程度等具有一定临床价值。

     

    Abstract: Objective To evaluate the clinical significance of joint detection of urine β2-microglobulin(β2-MG),albumin(Alb) and immunoglobulin G(IgG) in patients with hyperthyroidism. Methods Urine β2-MG, Alb, IgG and serum thyroid hormone free trilute(FT3), free thyroxin(FT4) of 45 healthy volunteers(as control group) and 120 patients with hyperthyroidism were measured by radioimmunoassay(RIA). Results The urine β2-MG, Alb and IgG in the hyperthyroidism group(including the primary group(group A) and uncured group(group B) ) were distinctly higher than those in control group and hyperthyroidism cured group(group C) (t=6.682,P<0.01).It was distinctly higher in hyperthyroidism group B than that in hyperthyroidism group A(t=2.385, P<0.05). And there was no distinct difference between the control group with hyperthyroidism group C in urine prMG, Alb and IgG (t=0.568, P>0.05).There was favorable correlation between the urine β2-MG, Alb and IgG with serum FT3 and FT4(the related coefficients were 0.98, 0.88, 0.93, 0.87, 0.94, and 0.85 respectively).Conclusion It is important to measure urine β2-MG together with Alb and IgG in early judgment of the location and degree of kidney injury, as well as the severity of disease in patients with hyperthyroidism.

     

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