Abstract: Epilepsy is a very complicate and synthetic disease which influence patients intelligence and daily life acutely. But the cure rate of epilepsy is much low. One of the results is precise localization of disease which result in epilepsy. Today the main methods are electroencephalogram, magnetic resonance imaging, magnetic resonance spectroscopy and PET cerebral imaging. PET cerebral imaging can locate epileptic foci of epilepsy from the brain organization metabolism, blood, the bio-chemical, function and oxygen consume, the chemistry pass quality and nerve receptor. It raises the rate of checking the epileptic foci and indicates a direction for the next treatments of epilepsy.