多巴胺转运体显像剂11C-CFT和18F-CFT及其临床应用进展

Dopamine transporter imaging agent 11C-CFT and 18F-CFT and its clinical application development

    摘要
  • 摘要: 使用11C和18F标记的托烷类衍生物的正电子显像剂是目前临床常规使用的正电子显像剂,11C标记的显像剂11C-2β-碳甲氧基-3β-(4-氟苯基)托烷(11C-CFT)具有合成方法简单、比活度高、成本低等优点,但是11C半衰期太短而限制了其临床使用;18F-CFT具有半衰期长、临床使用方便而受到重视。11C-CFT和11F-CFT PET均被用于临床早期诊断帕金森病和对药物治疗疗效的监测。

     

    Abstract: 18F and 11C marked tropane derivatives is routing used PET tracer. 11C marked 11C-2β.carbomethoxy-3β-(4-fluorophenyl) tropane (11C-CFT) synthesis method is simple, have high specific activity and low cost, but 11C short half life limited the clinical application of 11C-CFT.18F-CFT was much accounted of due to long half life and easy to access.11C-CFT and 18F-CFT was both used in Paricinson disease early diagnosis and monitoring of pharmaceutical theraoy.

     

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