Abstract: Objective To evaluate the outcomes of stress-rest ⁹⁹Tc^m-MIBI perfusion imaging in patients with percutaneous transluminal coronary angioplasty (PTCA). Methods Twenty patients with coronary heart disease underwent repeated ⁹⁹Tc^m-MIBI stress-rest perfusion imaging before and after PTCA, and semi-quantitative analysis, 8 cases of them repeated coronary angiography after 6 monthes. Results Twenty patients with total of 27 coronary artery stenosis were distended, the average vascular stenosis were (84.3 ±9.2)% before PTCA, and were reduced to (31.2±9.1)% after PTCA. Stress-rest perfusion imaging showed myocardial segments were reversible defect (myocardial ischemia) from 55 (30.6%) befor PTCA to 10 (5.6%) after PTCA, there were significant difference (χ²=38.02, P<0.005). The improved rate was 81.8%, 8 patients underwent repeated stress-rest SPECT imaging after 6 monthes, 3 cases appears ischemia segment, and coronary angiography confirmed was restenosis. Conclusion ⁹⁹Tc^m-MIBI stress-rest perfusion imaging is a useful noninvasive method for evaluating the effect of PTCA and for restenosis.