Abstract: Nuclide molecule diagnosis and therapy breast cancer is developing quite quickly in recent years, and is the hot spot of study and research. The developing of polypeptide receptor labelling by radioactivity nuclide is the most active and youngest territory branch of nuclear medicine. The nearest representative of polypeptide drug including somatostatin analogue, ¹⁸F-fluoroestradiol, vasoactive intestinal peptide, interleukin-ll analogs nine-circellus polypeptide, 11β-metoxy-17α-¹²³I-iodovinylestradiol, this review the nearest progress of every polypeptide drug in diagnosis and therapy of breast cancer respectively.