Abstract: ¹⁸F-FDG PET has become the preferred method of staging and restaging of many malignant neoplasms. Its application has increased diagnostic accuracy and exerted a considerable impact on the treatment of patients. ¹⁸F-FDG PET has also become extremely valuable in therapy efficacy monitoring of many malignant neoplasms. Choline is critical for cellular membrane structures and function. Choline metabolism increases in malignant neoplasms. ¹¹C-/¹⁸F-choline PET has been used in diagnosis and detection of many malignant neoplasms and metastases. This paper reviews the value of ¹⁸F-FDG and ¹¹C-/¹⁸F-choline PET in tumors imaging and compares their advantages and limitations.