基于Citespace和Vosviewer的Micro-CT应用于实验动物研究的研究现状及研究热点可视化分析

Visual analysis of the research status and research hotspots of Micro-CT applied to experimental animal research based on Citespace and Vosviewer

    摘要
  • 摘要:
    目的 探讨Micro-CT应用于实验动物研究现状及热点。
    方法 检索Web of Science (WOS)核心合集数据库2014年1月1日至2024年7月31日发表的关于Micro-CT应用于实验动物研究的文献，采用CiteSpace6.3.R1、VOSviewer1.6.20、Origin、SCImago Graphica软件对纳入文献的文献类型、来源期刊、发文量、作者、国家、机构、 关键词等内容进行可视化分析。
    结果 共纳入英文文献610篇，涉及来源期刊314种，其中，刊载量最高的期刊为Bone，被引量居首的期刊为journal of bone and mineral research。Micro-CT应用于实验动物研究相关的文献年发文量整体呈上升趋势，发文量最多的国家以美国为主，纳入文献作者共4133名，来自1130家机构，涉及的机构多为高等院校、医学院校附属医院以及科研院所等，形成以来自巴西圣保罗大学Rafael Scaf de Molon等为核心的牙科研究团队以及与奥地利维也纳医科大学、韩国首尔延世大学牙科学院等其他牙科专家在牙科专业领域进行的小范围的合作。关键词共现分析、关键词聚类分析和关键词突现分析结果表明骨相关的疾病模型研究（骨质疏松、骨关节炎）以及基础研究（表达、再生、细胞、组织、表面修饰）；口腔种植术（牙龈卟啉单胞菌、口腔上颌窦提升术、牙科种植体）；生物材料植入（植入物）是当前研究热点和发展动向。
    结论 近10年来，Micro-CT在实验动物研究中的应用发展迅速，以美国为首的发达国家在该领域处于领先地位。骨相关的疾病模型研究如骨质疏松症、骨关节炎关节软骨相关研究，以及骨相关的基础研究如组织再生技术是该领域研究热点。但近年来的研究重点向Micro-CT在生物材料植入中的应用方向发展，可以作为未来研究方向的参考。

     

    Abstract:
    Objective To understand the application of Micro-CT in experimental animal research and predict the research hotspots and development trends in the future.
    Methods  The related literatures about Micro-CT applied in experimental animal research were searched in the Web of Science (WOS) core collection database. CiteSpace6.3.R1, VOSviewer1.6.20, Origin2024, Excel and SCImago Graphica software were used to visually analyze the countries, institutions, keywords and other contents of the included literature.
    Results A total of 610 articles were included. The annual number of articles related to Micro-CT application in experimental animal research was on the rise as a whole. 610 articles came from 55 countries, involving 1130 institutions, 4133 authors, and 314 journals. The United States was the country with the highest number of publications, and the institutions with the highest number of publications was University of Sao Paulo, Brazil,The author with the highest number of articles was Rafael Scaf de Molon, the most published journal was Bone, and the most cited journal was journal of bone and mineral research. Keyword Clustering showed that the main research areas of Micro-CT were bone regeneration, osteoporosis, osteoarthritis, dental implantation, and implants.
    Conclusion In the past decade, the application of Micro-CT in experimental animal research has developed rapidly, and the developed countries led by the United States are in a leading position in this field.The application of Micro-CT in biological implants is a current research hotspot and a future development trend.

     

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