Abstract: In September 2021, the Ministry of Ecology and Environment of China issued "Radiation Protection and Safety Requirements for Nuclear Medicine" (HJ 1188—2021). This standard systematically specifies radiation protection and safety management requirements for nuclear medicine diagnosis and treatment processes, including technical regulations regarding storage and discharge of radioactive wastewater. In recent years, with the development in the integrated diagnosis and treatment of ⁶⁸Ga/¹⁷⁷Lu, the influence of radioactive wastewater contained in the domestic wastewater of patients receiving radionuclide therapy on the medical environment, medical staff and surrounding ecology will become a key challenge to be dealt with in the construction and development of nuclear medicine department in hospital′s. Through biological dosimetry studies of ¹⁷⁷Lu radiopharmaceutical and measurements of radioactive doses in domestic wastewater following radionuclide therapy, it was concluded that domestic wastewater generated from patient bathing on the day and after ¹⁷⁷Lu radiopharmaceutical therapy can be directly discharged into the hospital's central wastewater treatment system. The authors analyze domestic and foreign policies and experiences in radiation protection and wastewater treatment, focusing on domestic wastewater after ¹⁷⁷Lu radiopharmaceutical therapy and the design planning of decay ponds in nuclear medicine. The authors aim to learn from international advanced management methods and technologies to promote the development of nuclear medicine in China.