Abstract:
Objective To investigate the influence of different reconstruction methods embedded in Siemens Biograph Vision 450 PET/CT on the image quality and standardized uptake value (SUV) of pulmonary lesions.
Methods Analyzing retrospective collection of patients who underwent whole body imaging in our department from March to July 2023. Total patients: 44, 33 males, 11 females, average age of 69 years old from 56 to 83. Image quality analysis of the patient images was conducted using different reconstruction methods embedded in Siemens Biograph Vision 450 PET/CT. The main reconstruction methods used are as follows: Backproject, Backproject+ Time of Flight (TOF), Iterative, Iterative+TOF. The influence of adding TOF to different reconstruction methods on image quality SUVSD, signal-to-noise ratio (SNR) and realative SNR and related SUVs is analyzed and compared using kappa and rank-sum test
Results The visual assessment of image quality scores shows a high degree of consistency, (Kappa=0.862, 95%CI: 0.745−0.979, P<0.001). Both Backprojection and Iterative can reduce noise and improve SNR after adding TOF, for Backprojection the SNR raised from 22.470(95%CI: 14.003−35.827) to 28.835(95%CI: 19.417−45.341) P=0.007 and for Iterative the SNR raised from 76.880(95%CI: 37.416−101.554) to 126.593(95%CI: 52.256−177.317) P=0.001. In terms of relative SNR, TOF method has a greater improvement on Iterative.
Conclusion When using the Iterative or Backprojection built-in in Siemens Biograph Vision 450 PET/CT for reconstruction of the pulmonary lesions, TOF can be added as needed. Iterative is more recommended to use.