Abstract: The author reported a case of delayed epiphyseal closure with right femoral neck fracture caused by pituitary dysfunction due to treatment of intracranial germ cell tumor using ⁹⁹Tc^m-methylenediphosphonate (MDP) whole-body bone imaging. The author reviewed the literature and summarized the clinical manifestations and pathogenesis. Through the analysising of this case, it was demonstrated that ⁹⁹Tc^m-MDP whole-body bone imaging can be used to detect delayed epiphyses closure in adults and fractures, which helps clinicians evaluate the condition and efficacy.