Abstract: Radiation-induced intestinal injury (RIII) is one of the most serious complications in patients with abdominal/pelvic tumors, which seriously affects the prognosis and quality of life of patients.There is no effective treatment strategy for RIII in current clinical findings, therefore, it is of great importance to study of new treatment strategy. At present, a large number of studies have shown that non-coding RNA plays an important role in the regulation of various physiological functions and the occurrence and development of diseases. The authors focuse on the regulatory roles of microRNA, long non-coding RNA and circular RNA in the regulation of the pathogenesis of RIII, in order to provide new ideas and new methods for the diagnosis and treatment of RIII.