Abstract: Cardiovascular radionuclide imaging is an irreplaceable technique for the diagnosis and management of cardiovascular diseases. With the increasing clinical needs, radionuclide imaging technique is facing higher requirements for precision diagnostics. To play a more important role, further updated technology and more reasonable clinical usage are needed for the commonly used radionuclide myocardial perfusion imaging and myocardial metabolic imaging. Meanwhile, more and more novel radionuclide imaging techniques are translating from clinical trials to daily practice to fulfill the needs of precision diagnostics and promote the development of nuclear cardiology.