Abstract: Tritium, a radionuclide, can enter the human body through various pathways, including the digestive tract, respiratory tract, skin surface and wounds, resulting in varying degrees of internal radiation damage to human health. In this paper, the characteristics, absorption and metabolism of tritium are briefly introduced, and the clinical medical treatment data of internal tritium contamination caused by several accidents at home and abroad are reviewed. The key points of treatment and enlightenment for internal tritium contamination are put forward.