杨兑明, 张磊, 段武德, 吴艳艳, 李庆华, 杨燕, 张红周. 基于DCE-MRI衍生参数在脑囊虫病所致癫痫复发评估中的价值研究[J]. 国际放射医学核医学杂志. DOI: 10.3760/cma.j.cn121381-202307002-00396
引用本文: 杨兑明, 张磊, 段武德, 吴艳艳, 李庆华, 杨燕, 张红周. 基于DCE-MRI衍生参数在脑囊虫病所致癫痫复发评估中的价值研究[J]. 国际放射医学核医学杂志. DOI: 10.3760/cma.j.cn121381-202307002-00396
Duiming Yang, Lei Zhang, Wude Duan, Yanyan Wu, Qinghua Li, Yan Yang, Hongzhou Zhang. Study on the value of DCE-MRI derived parameters in the evaluation of epilepsy recurrence caused by cerebral cysticercosis[J]. Int J Radiat Med Nucl Med. DOI: 10.3760/cma.j.cn121381-202307002-00396
Citation: Duiming Yang, Lei Zhang, Wude Duan, Yanyan Wu, Qinghua Li, Yan Yang, Hongzhou Zhang. Study on the value of DCE-MRI derived parameters in the evaluation of epilepsy recurrence caused by cerebral cysticercosis[J]. Int J Radiat Med Nucl Med. DOI: 10.3760/cma.j.cn121381-202307002-00396

基于DCE-MRI衍生参数在脑囊虫病所致癫痫复发评估中的价值研究

Study on the value of DCE-MRI derived parameters in the evaluation of epilepsy recurrence caused by cerebral cysticercosis

  • 摘要:
    目的 探讨基于DCE-MRI衍生参数在脑囊虫病(CC)所致癫痫复发评估中的价值。
    方法 回顾性分析2020年1至12月于云南省保山市第二人民医院接受治疗的CC所致癫痫急性发作患者40例,其中男性22例、女性18例,年龄(35.6±11.0)岁。依据在半年内癫痫是否复发,将所有患者分为复发组和不复发组。分别于患者首次入院和随访半年后观察和记录所有患者的动态对比增强MRI(DCE-MRI)衍生参数:速率常数(Kep)、容积转移常数(Ktrans)和血管外细胞外间隙容积分数(Ve),评估2组患者血脑屏障(BBB)的通透性。组间比较采用独立样本t检验或χ2检验。
    结果 40例患者中,复发组16例、不复发组24例。2组患者的性别、年龄、癫痫首次发作时间和癫痫类型的差异均无统计学意义(χ2=0.020,t=0.692,t=0.902,χ2=0.030,均P>0.05)。首次入院检测时,不复发组患者的Kep、Ve和Ktrans水平分别为(30.17±5.32)×10−2/min、(102.32±6.58)×10−2、(19.98±2.64)×10−2/min,显著低于复发组 (36.32±4.36)×10−2/min、(110.35±7.12)×10−2、(23.21±3.21)×10−2/min,且差异均有统计学意义(t=3.839、3.660、3.477,均P<0.001)。随访半年后检测时,不复发组患者的Kep、Ve和Ktrans水平分别为(12.57±3.29)×10−2/min、(78.02±4.36)×10−2、(17.96±3.01)×10−2/min,亦显著低于复发组(24.25±3.58)×10−2/min、(90.37±8.27)×10−2、(23.32±3.98)×10−2/min,且差异均有统计学意义(t=10.620、10.161、4.848,均P<0.001)。
    结论 基于DCE-MRI衍生参数可以分析BBB通透性,对CC所致癫痫的复发评估具有重要价值。

     

    Abstract:
    Objective To explore the value of derived parameters based on DCE-MRI in the evaluation of epilepsy recurrence caused by cerebral cysticercosis (CC).
    Methods 40 patients with acute epilepsy caused by CC treated in the second people's Hospital of Baoshan City, Yunnan Province from January to December 2020 were analyzed retrospectively, including 22 males and 18 females, aged (35.6 ±11.0) years. According to the recurrence of epilepsy within half a year, all patients were divided into recurrent group and non-recurrent group. The dynamic contrast enhanced MRI (DCE-MRI) derivative parameters, such as rate constant (Kep), volume transfer constant (Ktrans) and extracellular space volume fraction (Ve), were observed and recorded in all patients at first admission and half a year after follow-up, respectively. The permeability of blood-brain barrier (BBB) was evaluated in two groups. Independent sample t-test or χ2 test was used for inter-group comparison.
    Results There was no significant difference in general data such as gender, age, first onset time, and epilepsy types between the two groups(χ2=0.020, t=0.692, t=0.902, χ2=0.030, all P >0.05). At the first admission, the levels of Kep, Ve and K trans in the non-recurrent group were (30.17±5.32)×10−2/min, (102.32±6.58)×10−2 and (19.98±2.64) × 10−2/min, respectively, which were significantly lower than those in the recurrent group (36.32±4.36)×10−2/min, (110.35±7.12)×10−2, (23.21±3.21)×10−2/min (t=3.839、3.660、3.477, all P<0.001). After half a year of follow-up, the levels of Kep, Ve and Ktrans in the non-recurrent group were (12.57±3.29)×10−2/min, (78.02±4.36)×10−2 and (17.96±3.01)×10−2/min, respectively, which were also significantly lower than those in the recurrent group (24.25±3.58)×10−2/min, (90.37±8.27)×10−2, (23.32±3.98)×10−2/min, and the differences were statistically significant (t=10.620、10.161、4.848, all P<0.001).
    Conclusion Using DCE-MRI derived parameters can analyze the BBB permeability to distinguish the recurrence of epilepsy caused by CC.

     

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