Abstract: In the past, the diagnostic evaluation of diseases by SPECT was mainly at the qualitative or semi-quantitative level. With the development of SPECT imaging combined with CT and image reconstruction techniques, SPECT has been able to perform quantitative assessments in a manner similar to PET and has been applied to the circulatory, endocrine, neurological and skeletal systems of the human body. SPECT imaging is the most widely used imaging method for detecting bone metastases because it can sensitively detect abnormalities in the metabolic function of bones at an early stage, and sensitively detect bone metastases at the initial stage of bone metastases formation when there are no changes in the skeletal anatomical structure. With the development of SPECT imaging techniques, SPECT/CT fusion imaging can improve the specificity of bone scans by attenuation correction techniques with fused CT anatomical structure images. While conventional SPECT/CT provides a subjective visual assessment by lesion uptake of tracer, the use of quantitative SPECT/CT parameters allows for an objective and accurate assessment of skeletal lesions. The development of SPECT/CT quantitative technology has received general attention. Combining the results of relevant clinical studies at home and abroad, the authors discusse the quantitative methods of SPECT/CT quantitative technology and its research progress in skeletal system diseases, expecting that the quantitative methods can be applied to more fields of SPECT/CT diagnosis, and establishing relevant criteria.