Abstract: The skin is the largest organ of the human body. In tumor radiotherapy or accidental radiation accidents, the skin will receive different doses of radiation, resulting in radiation-induced skin injury (RISI). Clinical treatment of RISI is mainly symptomatic treatment, lack of effective targeted drugs. Therefore, it is very important to study safe and effective drugs for the prevention and treatment of RISI. This paper reviews the research progress of RISI prevention and treatment drugs at home and abroad in recent years, in order to provide reference for the research of RISI prevention and treatment drugs.