宋乐乐, 邱永康, 张潇月, 康磊. 18F-FDG PET/CT在IgG4相关心血管疾病中的应用进展[J]. 国际放射医学核医学杂志. DOI: 10.3760/cma.j.cn121381-202303013-00390
引用本文: 宋乐乐, 邱永康, 张潇月, 康磊. 18F-FDG PET/CT在IgG4相关心血管疾病中的应用进展[J]. 国际放射医学核医学杂志. DOI: 10.3760/cma.j.cn121381-202303013-00390
Lele Song, Yongkang Qiu, Xiaoyue Zhang, Lei Kang. Research progress of 18F-FDG PET/CT in IgG4 related cardiovascular diseases[J]. Int J Radiat Med Nucl Med. DOI: 10.3760/cma.j.cn121381-202303013-00390
Citation: Lele Song, Yongkang Qiu, Xiaoyue Zhang, Lei Kang. Research progress of 18F-FDG PET/CT in IgG4 related cardiovascular diseases[J]. Int J Radiat Med Nucl Med. DOI: 10.3760/cma.j.cn121381-202303013-00390

18F-FDG PET/CT在IgG4相关心血管疾病中的应用进展

Research progress of 18F-FDG PET/CT in IgG4 related cardiovascular diseases

  • 摘要: 免疫球蛋白G4相关疾病(IgG4-RD)是一种全身炎症性疾病,通常累及多个器官。IgG4相关心血管疾病(IgG4-RCVD)包括IgG4相关主动脉病变、IgG4相关冠状动脉病变、IgG4相关肺动脉病变和IgG4相关心包炎。IgG4-RCVD受累部位IgG4阳性浆细胞聚集并高表达葡萄糖转运蛋白。18F-氟脱氧葡萄糖(FDG)PET/CT可以基于IgG4-RCVD患者病变部位的代谢程度在全身范围内评估血管炎症的范围和程度,在诊断和定量评估IgG4-RCVD血管炎症、指导活检部位选择以及疗效监测等方面起到关键作用。笔者对18F-FDG PET/CT在IgG4-RCVD应用中的进展进行综述,以期为临床医师通过18F-FDG PET/CT诊断IgG4-RCVD提供参考。

     

    Abstract: Immunoglobulin G4-related disease (IgG4-RD) is a type of systemic inflammatory diseases that often affect multiple organs. IgG4-related cardiovascular disease (IgG4-RCVD) includes IgG4-related aortic disease, IgG4-related coronary artery disease, IgG4-related pulmonary artery disease, and IgG4-related pericarditis. IgG4-positive plasma cells accumulate and exhibit high expression of glucose transport proteins at the site of IgG4-RCVD involvement. 18F-fluorodeoxyglucose (FDG) PET/CT can assess the extent and degree of vascular inflammation on a systemic scale by evaluating the metabolic activity of lesions in IgG4-RCVD patients. It plays a pivotal role in diagnosing and quantitatively assessing IgG4-RCVD vascular inflammation, aiding in the selection of biopsy sites, and monitoring treatment efficacy. The authors conducted a comprehensive review of the advancements in the utilization of 18F-FDG PET/CT for IgG4-RCVD, aiming to furnish clinicians with a valuable reference for diagnosing IgG4-RCVD through the application of 18F-FDG PET/CT.

     

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