Abstract: Gastric cancer is one of the most common malignant tumors in China, with significant tumor heterogeneity in biology and genetics. PET is a non-invasive, real-time in vivo examination method. The use of PET imaging for early detection, treatment planning and efficacy monitoring is helpful to assist diagnosis and prognosis, improve the five-year survival rate of gastric cancer patients, and help clinicians to diagnose and identify its heterogeneity, so as to select individualized treatment plans. Therefore, the research of specific probes for gastric cancer based on PET imaging has been highly valued by researchers. The author summarized the hot research on specific targets and corresponding molecular probes for gastric cancer, describes and analyzes their development history and research results, hoping to provide reference and guidance for the development of novel PET imaging probes for gastric cancer.