Abstract: Amyloidosis is the accumulation of amyloid in the cells of various organs in the body caused by various reasons, resulting in the gradual failure of the affected organs. When amyloid affects the heart, known as cardiac amyloidosis (CA), the prognosis is the worst. In CA, transthyretin amyloidosis and immunoglobulin light chain amyloidosis are the most common, and there are huge differences in the median survival time and treatment methods of the two. Therefore, early diagnosis and accurate classification are crucial for the treatment of such patients. Nuclear medicine imaging can non-invasively diagnose and accurately classify CA, and has been widely used in clinical practice. This article reviews the recent progress of nuclear medicine imaging in CA to improve clinicians' understanding of CA and facilitate early diagnosis of CA.