Abstract: It is crucial that the autonomic nervous system plays a crucial role in regulating cardiovascular function and intact innervation is the basis for normal cardiovascular function. Many cardiac diseases have had neurological alterations before the development of organic lesions, which can be evaluated by PET imaging of radionuclide labeled neurotransmitter analogues. It can sensitively reflect the integrity of cardiac autonomic nervous function, the secretory function and activity of neurons, and provide early diagnosis and timely intervention for cardiovascular disease. In recent years, carbon-11 labeled cardiac sympathetic nerve receptor imaging agents have developed rapidly. The author reviews the new progress of several imaging agents.