Abstract: Cell adhesion factor integrin αvβ3 is highly expressed in the surface of neovascularization endothelial cells and cells of many kinds of tumors, including gliomas, while it is low or not expressed in the surface of normal cells. Arginine-glycine-aspartic acid (RGD) peptides can specifically bind to integrin αvβ3. Radionuclide-labeled RGD peptide has become the research focus of targeted imaging of glioma. RGD PET imaging has certain value in the diagnosis and curative effect monitoring of glioma. Based on this, this article reviews the application of RGD PET imaging in the diagnosis and treatment of glioma.