Abstract: The removal of skin contamination from radioactive nuclides is a key measure to prevent further harm to the human body. Based on the strategies for removing skin contamination from radioactive nuclides at home and abroad, the authors summarize the currently available and under research decontaminating agent of radionuclides from skin, including several aspects such as chitosan derivatives, organic phosphates, polymer, organic skeleton materials, which have the potential to become candidate formulations for the removal of skin contamination from radioactive nuclides. The aim is to provide reference for future research on new formulations for the removal of skin contamination from radioactive nuclides.