Abstract: Altitude sickness refers to a series of clinical syndromes caused by incomplete or maladjustment of adaptability after the human body enters the high altitude hypobaric and hypoxic environment. The disease has become a major public health problem faced by sojourners on the plateau, which can be life-threatening in serious cases. Therefore, there is an urgent need to develop new methods for early diagnosis and treatment monitoring of altitude sickness. Clinical imaging techniques such as X-ray, CT, MRI, ultrasound, SPECT and PET have become practical tools for clinical diagnosis and treatment of altitude sickness. This article summarizes the application of various medical imaging techniques in the diagnosis and treatment evaluation of altitude sickness, in order to provide new ideas for the accurate diagnosis and treatment of altitude sickness.