Abstract: The authors reported a rare case of primary follicular lymphoma (PFL) coexist with papillary thyroid carcinoma (PTC), the fine-needle aspiration biopsy of thyroid nodule was diagnosed with lymphoma preoperative, but the postoperative histopathological result was PFL coexist with PTC. The authors analyzed the characteristics of PFL and PTC, and carried out literature review, through the treatment and follow-up observation of this case, the authors hoped to share the limited experience in imaging diagosis, treatment and follow-up of this type of case.