Abstract:
Fibroblast activator protein (FAP) is a marker protein of tumor-associated fibroblasts, which is highly expressed in many epithelial-derived malignant tumors but hardly expressed in normal tissues, and has become an important target for tumor diagnosis and treatment.
68Ga-labeled fibroblast activator protein inhibitor (FAPI) PET/CT imaging has the characteristics of not being affected by blood glucose level, rapid tumor uptake and it can obtain high tumor-to-background ratio images, which has shown a good prospect of clinical application. The pathogenesis of gastric and colorectal tumors is concealed, they are prone to recurrence and metastasis, peritoneal metastasis in particular are not easy to detect and the prognosis is poor. Compared with
18F-fluorodeoxyglucose (FDG) PET/CT examination,
68Ga-FAPI-04 PET/CT has significant advantages in the diagnosis, staging and efficacy evaluation of gastric and colorectal tumors, at present, it has attracted the attention of scholars at home and abroad. The author focuses on the clinical value and research progress of
68Ga-FAPI PET/CT in the diagnosis and treatments of gastric and colorectal tumors.