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随着核能和核技术的开发和利用,放射性装置已在工业、农业、国防、医学以及科学研究等各个领域得到了广泛应用。放射工作人员在工作过程中可能会受到低剂量电离辐射,存在一定的辐射损伤风险[1-2],因此,国家相关标准严格规定,需要定期对放射工作人员进行人外周血淋巴细胞染色体畸变和微核的检测及评价。DB11/T 1930—2021《放射工作人员健康检查染色体畸变和微核检测质量控制规范》从基本要求、实验室及仪器设备要求、染色体畸变及微核检测过程等全方面对这2个遗传学检测的质量控制进行了规定。为更好地指导放射工作人员健康体检机构在遗传学检测方面的工作,笔者对该标准进行了解读。
北京市地方标准DB11/T 1930—2021 《放射工作人员健康检查染色体畸变和微核检测质量控制规范》 解读
Interpretation of Beijing local standard DB11/T 1930—2021 Quality control specification for tests of chromosome aberration and micronucleus in radiation workers' health examinations
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摘要: 为正确贯彻执行北京市地方标准DB11/T 1930—2021 《放射工作人员健康检查染色体畸变和微核检测质量控制规范》,更好地指导放射工作人员健康体检机构遗传学检测工作,笔者对该标准的制定背景、主要依据及主要技术内容进行了解读。该标准是在广泛调研国内外文献的基础上,依据相关法律法规及国家和行业标准,并广泛征求同行专家意见的基础上制定的。该标准规定了放射工作人员健康检查中,开展人外周血淋巴细胞染色体畸变检测和微核检测的基本要求、实验室和仪器设备的要求以及试验过程中的质量控制。对该标准的解读可指导放射工作人员健康检查机构遗传学实验室更加规范、科学地开展工作,更好地保障放射工作人员的安全和健康。Abstract: In order to correctly implement the Beijing local standard DB11/T 1930—2021 Quality control specification for tests of chromosome aberration and micronucleus in radiation workers' health examinations, and better guide the cytogenetic testing for radiation workers in health examination institutions, the background, main basis and main technical content of the standard were interpreted. This standard was formulated on the basis of extensive research on domestic and foreign literature, in accordance with relevant laws and regulations, national and industry standards, and on the basis of extensive consultation with peer experts . The basic requirements, laboratory and equipment requirements, and quality control for the test process of chromosomal aberrations and micronucleus in human peripheral blood lymphocytes during the health examination of radiation workers were specified in this standard. The interpretation of the standard can be used to guide the genetic laboratory of the occupational health examination institution of radiation workers to work in a more standardized and scientific way, and better ensure the safety and health of the radiation workers.
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Key words:
- Quality control /
- Chromosome aberrations /
- Micronucleus tests /
- Specification /
- Radiation workers
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