原发性中枢神经系统淋巴瘤的影像学研究进展

Research progress of neuroimaging in primary central nervous system lymphoma

摘要: 原发性中枢神经系统淋巴瘤（PCNSL）是一种罕见且侵袭性极强的结外非霍奇金淋巴瘤，其占所有结外淋巴瘤的4%~6%，原发性中枢神经系统肿瘤的4%。近年来，PCNSL发病率呈逐年上升趋势，其确诊主要依靠组织病理学检查，包括立体定向活体组织病理学检查和（或）手术期间的组织病理学检查，然而这2种方法均风险较高且并发症较多。因此，寻找能准确评估PCNSL的无创性影像学方法就显得尤为重要。目前，临床常用于评价PCNSL的影像学检查方法主要有CT、 MRI、 PET/CT和PET/MRI。笔者主要对近年来PCNSL的影像学研究进展进行综述。

Abstract: Primary central nervous system lymphoma (PCNSL) is relative rare and highly aggressive extranodal non-Hodgkin's lymphoma, accounting for 4%−6% of all extranodal lymphomas and 4% of primary central nervous system tumors. In recent years, a rising incidence has been recognized. The diagnosis of PCNSL mainly depends on stereotactic biopsy histopathological examination and surgical pathology. However, these procedures have high risks and multiple complications. Therefore, it is especially necessary to find a reliable non-invasive imaging method to evaluate PCNSL accurately. CT, MRI, PET/CT and PET/MRI are used to evaluate PCNSL currently. This review focuses on the research progress of neuroimaging in PCNSL.