Abstract: Hypothyroidism is often combined with dyslipidemia such as elevated serum cholesterol and triglyceride levels, which is one of the major risk factors for atherosclerotic cardiovascular disease, and seriously affects patients' quality of life and survival. This paper reviews the recent research progress on the regulation of thyroid hormone on lipid metabolism, the effect of hypothyroidism and subclinical hypothyroidism on lipids, and the treatment of hypothyroidism combined with dyslipidemia, in order to provide reference for the prevention and treatment of hypothyroidism combined with dyslipidemia.