Abstract: In recent years, the detection rate of differentiated thyroid cancer (DTC) has increased significantly due to the wide application of high-resolution ultrasonography and fine needle aspiration biopsy. Cervical lymph nodes metastases (CLNM) is the most common type of postoperative persistent/recurrent disease in DTC patients, and its diagnosis and treatment involve multiple disciplines. At present, the most common diagnostic method and the "gold standard" is cervical ultrasound and histopathological examination respectively. The main treatment is operation. In addition, some alternative treatments such as ¹³¹I therapy, ultrasound-guided ablation and follow-up observation have gradually been proposed and applied in clinical practice. The authors review the diagnosis and treatment of postoperative persistent/recurrent CLNM in DTC patients.