Abstract: The authors reported a case of chronic renal insufficiency with long-term peritoneal dialysis calciphylaxis and left ventricular metastatic calcification with ⁹⁹Tc^m-medronate (MDP) SPECT/CT imaging. The imaging results showed left ventricle metastatic calcification and lower limb calciphylaxis abnormal radioactive concentration of ertraosseous soft tissue. The authors analyzed the characteristics of the disease from the aspects of clinical symptoms, laboratory examinations and imaging findings, and deepened the understanding of the pathogenesis of calciphylaxis and metastatic calcification through literature review.