Abstract: More and more studies have shown that children with congenital heart disease (CHD) will suffer from brain developmental deficiency. Recently, how to predict the brain development of children with CHD based on imaging data in the early stage has become a hot issue. Ultrasound and MRI have been proven to predict the brain development of children with CHD, and play an important role in the early assessment and intervention. In this paper, the current research status and progress of imaging-based prediction models in the brain development of children with CHD are reviewed, aiming to provide references for clinical treatment and follow-up.