Abstract: A case of double lung multiple nodular amyloidosis with ¹⁸F-fluorodeoxyglucose (FDG) PET/CT imaging was reported. The characteristics of the disease were analyzed from clinical symptoms, imaging manifestations and pathological diagnosis. The understanding of pulmonary amyloidosis was deepened through literature review. The incidence of pulmonary nodular amyloidosis is low, the clinical symptoms are atypical, and it is difficult to differentiate from common lung tumors. It is suggested that the possibility of pulmonary nodular amyloidosis should be considered in the differential diagnosis of pulmonary nodules. Therefore, ¹⁸F-FDG PET/CT imaging is very important to evaluate the extent of double lung multiple nodular amyloidosis.