Abstract: The easy Z-score imaging system (eZIS) is a statistical analysis method based on statistical parametric mapping and three-dimensional stereotactic surface projection to assist the automatic diagnosis of cerebral blood perfusion SPECT imaging, which can be used in the diagnosis of nervous system diseases such as dementia, Parkinson disease, ataxia and motor neuron disease. Compared with other computer-aided analysis methods, eZIS can provide a normal database, and realize data sharing among different institutions through image conversion program, so that the future multi-center, large sample clinical research is possible. In this review, the clinical application of eZIS in the diagnosis of neurodegenerative dementia by cerebral blood perfusion SPECT is reviewed in order to improve clinicians' understanding of eZIS and promote its application in clinical and scientific research work.