Abstract: Parkinson disease (PD) is the second most common neurodegenerative disease in middle-aged and elderly people. To date, there is no effective treatment methods for this chronic disease in clinical. Cardiac neuroreceptor imaging can visualize the integrity and functional status of cardiac sympathetic nerves, it is a sensitive indicator for evaluating cardiac sympathetic nerve function, which is particularly important for the diagnosis and differential diagnosis of early PD. The authors focused on the latest progress research of cardiac neuroreceptor imaging in the diagnosis and differential diagnosis of PD.