Abstract: The authors report a case of hepatic paragonimiasis with ¹⁸F-fluorodeoxyglucose PET/CT imaging, which is rare in clinic and easily misdiagnosed as hepatocellular carcinoma, cholangiocarcinoma or liver abscess. After entering the human body, paragonimiasis can lead to multi-system and multi-organ lesions. PET/CT as a systemic examination can find more organs involved, so as to make a more accurate diagnosis of liver paragonimiasis, strengthen understanding and reduce misdiagnosis.