Abstract: A case of multiple intraosseous hemangioma (IH) with ¹⁸F-fluorodeoxyglucose (FDG) PET/CT imaging was reported, which was differentiated from the aspects of clinical symptoms, laboratory examinations and imaging findings. IH in different location have different imaging findings, and ¹⁸F-FDG PET/CT can provide a reference for clinical differentiation of benign and malignant tumors. As it was rare to find IH in flat bones, whose imaging findings were lack of specificity, the authors analyzed the ¹⁸F-FDG PET/CT imaging characteristics in order to improve the understanding of imaging physicians about the disease.