Abstract: The curative efficacy and safety of the ¹³¹I therapy of Graves' disease have been recognized by most domestic and international scholars, but the choice of the specific therapeutic dose is still controversial. According to different therapeutic targets, the choice of the dose-determination scheme is also different. Domestic scholars mostly choose the combination of calculated dose method individualized scheme, while foreign scholars mostly choose the fixed dose scheme. This article reviews the dose-determination schemes of ¹³¹I therapy for Graves' disease.