Abstract: Standardized uptake value (SUV) is the most important semi-quantitative index in the clinical application of ¹⁸F-FDG PET/CT. It plays an important role in the diagnosis of various diseases, evaluation of therapeutic efficacy and prognosis in tumors. However, the accuracy of SUV measurement can be affected by many factors, such as biological and technical factors. This review summarizes the influencing factors on the accuracy of SUV measurement and their solutions in order to provide assistance for clinical setting.