Abstract: COVID-19 has been rapidly spreading since its discovery. Early diagnosis benefits the patients and helps control the spread of COVID-19. At present, the diagnosis of COVID-19 is based on epidemiology, clinical characteristics, imaging features, and reverse transcription-polymerase chain reaction (RT-PCR) test. The diagnosis of COVID-19 is confirmed by RT-PCR test, which detects a positive severe acute respiratory syndrome coronavirus 2 nucleic acid. Imaging features, especially lung high-resolution CT features, are essential for the clinical diagnosis of COVID-19. ¹⁸F-FDG PET/CT is a widely used imaging modality, but its value for COVID-19 diagnosis is still unknown. This review summarizes the potential value of ¹⁸F-FDG PET/CT for the diagnosis, differential diagnosis, and assessment of mediastinal lymph node involvement. The possible imaging features of extrapulmonary involvement in patients with COVID-19 are also discussed.