Abstract: Exposure to ionizing radiation will lead to the injury of various tissues and organs, among which the skin is the first organ exposed to radiation. Therefore, the machanism and treatment of the injury are one of the research hotpots. Radiation-induced skin injury (RISI) is most common after medical radiotherapy, but also can be seen in accidents such as nuclear industry production, radioactive laboratories, industrial flaw detection and other accidental nuclear accidents. After RISI is formed, it affects the health status and quality of life of the patient, and even leads to death. However, there is no standard treatment for RISI so far. This review summarizes the treatment of RISI in order to provide reference for its clinical treatment and further research.