Abstract: The authors reported 2 cases of multislice spiral CT (MSCT) imaging findings with the greater omentum infarction in children, and summarized the diagnostic value of MSCT for the disease. Greater omentum infarction in children is relatively rare, and the clinical manifestation of the disease is not specific, the onset is similar to acute appendicitis or cholecystitis. For diagnosing the disease of the omentum infarction, ultrasound shows limitations, whereas the MSCT is the major method and has the specificity in the diagnosis. In children with secondary omental torsion and infarction, the disease progresses rapidly, and it is easy to be complicated with diffuse peritonitis without timely and accurate diagnosis and treatment, which endangers the lives of children. MSCT is helpful for showing the degree, extent, and complications of this disease and can be the first method used to avoid missed or erroneous diagnosis.