Abstract: The study reported a COVID-19 case performed with asthenia, fever as the first symptom, unclear history of epidemiology, laboratory examination implied bacterial infection. Chest CT imaging examination on the 8th day after onset indicated suspected case and finally confirmed by nucleic acid detection. The disease is a respiratory infectious disease caused by a novel corona virus. It is highly communicable. Some patients had multiple visceral involvement, and the disease progressed rapidly. This case is the first case of regional aggregation. The authors are trying to imply that patients with high-risk occupation but without a clear history of epidemiology should pay enough attention to the clinical work of COVID-19 and control. Early chest CT imaging examination and repeated nucleic acid tests for suspected cases are helpful to reduce ignored diagnosis.