Abstract: Corona virus disease 2019 (COVID-19) has been discovered and spread quickly since December 2019. It is extremely important to protect the staff and patients in nuclear medicine department during the epidemic period. Nuclear medicine diagnosis and treatment work, such as outpatient service, imaging tests, clinical examinations and radionuclide ward treatments, involves many workplaces and relatively complex procedures. Therefore, the requirements for the protection and management of staff and patients in all aspects of the process and the environmental disinfection of workplaces should be more stringent. Based on relevant national guidelines and the actual situation, this paper puts forward protection and management proposals on nuclear medicine diagnosis and treatment work during the COVID-19 epidemic period to ensure the safety of staff and patients.