Objective To evaluate the therapeutic effects of ⁹⁰Sr applicator and CO₂ laser treatment on condyloma acuminata (CA).

Methods Searched PubMed, China national knowledge infrastructure, Wanfang, cqvip, and other literature databases for Chinese and English articles related to the use of ⁹⁰Sr applicator and CO₂ laser treatment for patients with CA from 2000 to 2017. Eligible studies were collected according to the inclusion and exclusion criteria. The Jadad scal was used to evaluate the quality of the included articles. The standard used a 0–5 point scoring method. A score of ≤2 was regarded as low-quality evidence, and a score of ≥3 was regarded as high-quality evidence. Meta-analysis was performed on count data by using Stata 12.0 software to calculate pooled odds ratio (OR) and 95% confidence interval (CI). χ² test was used to assess the heterogeneity of the articles, and Begg's test and funnel plot method were used to detect the publication bias of the included articles.

Results This work included three eligible Chinese studies (a total of 228 patients) published from 2003 to 2011. The Jadad scores of the three articles were 4, 4, and 3 points, respectively. Heterogeneity was not detected among the included articles (cure rate: I²=0, P=0.685; recurrence rate: I²=0, P=0.954). The Begg's test (Z=0.045, P>0.05) and the funnel plot method showed no publication bias among the included articles. The merge OR of ⁹⁰Sr applicator on the cure rate of CA was 1.05, with 95%CI of 0.72–1.54. The merge OR of ⁹⁰Sr applicator on the recurrence rate of CA was 0.06, with 95%CI of 0.02–0.24.

Conclusion ⁹⁰Sr applicator is an effective clinical treatment that has similar therapeutic effects and lower recurrence rate than CO₂ laser.