正常前列腺18F-FDG PET/CT代谢显像增龄变化的研究

Study on 18F-FDG PET/CT metabolic imaging of normal prostate with increasing age

    摘要
  • 摘要:
    目的 探讨18F-氟脱氧葡萄糖（FDG） PET/CT显像中正常前列腺标准化摄取值（SUV）、CT值、PET/CT横断位最大层面测量的前列腺左右径（简称最大横径）和患者年龄之间的关系。
    方法 回顾性分析2018年6月至2019年2月在安徽医科大学第二附属医院行18F-FDG PET/CT显像的非前列腺癌男性患者181例，年龄19~94(60.6±14.5)岁。将患者按年龄段分为4组：19~39岁16例、40~59岁57例、60~79岁94例、80~99岁14例。采用勾画感兴趣区（ROI）的方法测量各组患者前列腺18F-FDG最大标准化摄取值(SUVmax)、平均标准化摄取值（SUVmean）和平均CT值（CTmean），并在前列腺横断位最大层面测量前列腺最大横径。采用Pearson相关性分析、散点图和线性回归趋势线分析前列腺最大横径、SUVmax、SUVmean、CTmean和年龄之间的相关性，采用单因素方差分析及LSD-t检验对各组患者相关参数的均值进行多重比较。
    结果 181例患者的前列腺最大横径为3.4~6.5（4.66±0.59） cm，SUVmax为1.0~4.2（2.44±0.49），SUVmean为0.7~3.4（1.97±0.44），CTmean为25~46（34.48±3.72） HU。前列腺最大横径与患者年龄呈正相关(r=0.465，P<0.001)；前列腺SUVmax、SUVmean与患者年龄、前列腺最大横径无相关性(r=0.047、0.071、0.040、0.035，均P>0.05)；前列腺CTmean随患者年龄的增长而增加，两者呈极弱相关性或无相关（r=0.126，P=0.091）。不同年龄段的各组患者的前列腺最大横径分别为（4.04±0.27）、（4.52±0.53）、（4.77±0.54）、（5.24±0.65）cm；SUVmax分别为（2.48±0.65）、（2.38±0.50）、（2.46±0.47）和（2.48±0.42）；SUVmean分别为（2.03±0.51）、（1.90±0.44）、（2.00±0.42）和（2.05±0.41）；CTmean分别为（33.25±3.59）、（34.19±3.76）、（34.76±3.80）、（35.29±2.97） HU。不同年龄段的各组患者前列腺最大横径之间的差异有统计学意义（F=16.278，P<0.001），而SUVmax、SUVmean和CTmean之间的差异均无统计学意义。
    结论 前列腺最大横径随着患者年龄的增长而增加，但患者年龄不会显著影响前列腺的糖代谢和CT密度。

     

    Abstract:
    Objective To investigate the correlations among standardized uptake value (SUV), CT value, maximum transverse diameter of normal prostate, and patient age through 18F-fluorodeoxyglucose (FDG) PET/CT.
    Methods Retrospective analysis of 181 male patients aged 19–94 (60.6±14.5) years who underwent 18F-FDG PET/CT in the Second Hospital of Anhui Medical University from June 2018 to February 2019 was performed. The patients were divided into four groups by age group (19–39 years, 16 cases; 40–59 years, 57 cases; 60–79 years, 94 cases; and 80–99 years, 14 cases). The maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), and mean CT value (CTmean) of prostate 18F-FDG were measured through a delineated region of interest method, and the maximum transverse diameter of the prostate was measured at the maximum transverse plane of the prostate. SPSS 16.0 statistical software was used in analyzing the correlations among the maximum transverse diameter of the prostate, SUVmax, SUVmean, CTmean, and age on the basis of the Pearson correlation coefficient, scatter plot, and linear regression trend line. One-way ANOVA and LSD-t test were used for each parameter.
    Results The maximum transverse diameter of the normal prostate was 3.4–6.5(4.66±0.59) cm, SUVmax was 1.0–4.2 (2.44±0.49), SUVmean was 0.7–3.4(1.97±0.44), CTmean was 25–46(34.5±3.72) HU. The maximum transverse diameter of the prostate was positively correlated with age (r=0.465, P<0.001). No significant correlation between prostate SUVmax, SUVmean and age, the maximum transverse diameter of the prostate (r=0.047, 0.071, 0.040, 0.035, all P>0.05). Prostate CTmean increased with age, and an extremely weak correlation or no correlation was observed between them (r=0.126, P=0.091). The maximum transverse diameters of all the age groups (19–39, 40–59, 60–79, and 80–99 years) were (4.04±0.27), (4.52±0.53), (4.77±0.54), and (5.24±0.65) cm, respectively, the SUVmax were 2.48±0.65, 2.38±0.50, 2.46±0.47, 2.48±0.42, respetively; the SUVmean were 2.03±0.51, 1.90±0.44, 2.00±0.42, and 2.05±0.41, respectively; and the CTmean were (33.25±3.59), (34.19±3.76), (34.76±3.80), and (35.29±2.97) HU, respectively. Significant differences were found among the maximum transverse diameters of the age groups (F=16.278, P<0.001), whereas no significant difference was found among SUVmax, SUVmean, and CTmean.
    Conclusion The maximum transverse diameter of the prostate increases with age, but age does not significantly affect the glucose metabolism and CT density of the prostate.

     

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