Abstract: Myocardial perfusion imaging plays an important role in the diagnosis and treatment of patients with known or suspected coronary artery disease. The cadmium-zinc-telluride (CZT)-based dedicated cardiac SPECT (called CZT-SPECT) with high resolution and photon sensitivity reduces radiation exposure and imaging time while improving image quality and enhancing the value of SPECT myocardial perfusion imaging in clinical practice. The review elaborates the clinical progress of CZT-SPECT.