Abstract:
Objective To investigate the effect of parathyroid lesion weight on the diagnostic sensitivity of 99Tcm-MIBI dual-phase plane imaging and 99Tcm-MIBI SPECT/CT tomography fusion imaging.
Methods A total of 22 patients with hyperparathyroidism that was confirmed via operation and pathology in the First People's Hospital of Kunshan were collected from February 2017 to October 2018. The patients included 9 males and 13 females aged 28–73 (50.77±8.79) years old. All patients underwent 99Tcm-MIBI biphasic imaging and 99Tcm-MIBI SPECT/CT fusion imaging in the early stage. The gold standard was postoperative pathological results. All resected lesions were divided into two groups: group A, wherein lesion weight ≤1.00 g, and group B, wherein lesion weight >1.00 g. χ2 test was used to analyze the diagnostic efficacy of the two imaging methods in the different weight groups.
Results A total of 58 lesions were removed from the 22 patients via surgical operation. The diagnostic sensitivity values of 99Tcm-MIBI dual-phase plane imaging for groups A and B were 47.83% (11/23) and 84.00% (21/25) respectively, and were statistically significantly different between the two groups (χ2=7.05, P=0.008). The diagnostic sensitivity values of 99Tcm-MIBI SPECT/CT early tomography for groups A and B were 78.26% (18/23) and 85.19% (23/27), respectively, and did not show significant differences between the two groups (χ2=0.40, P=0.525). In group A, the diagnostic sensitivity of 99Tcm-MIBI SPECT/CT early tomography was higher than that of dual-phase plane imaging; this difference was statistically significant (χ2=4.57, P=0.033). In group B, the diagnostic sensitivity of 99Tcm-MIBI SPECT/CT early tomography was higher than that of dual-phase plane imaging; however, no significant difference was observed (χ2=0.01, P=0.906).
Conclusions The weight of parathyroid lesions has an effect on dual-phase planar imaging. Specifically, sensitivity decreased when the parathyroid glands were light. However, lesion weight had no significant effect on the diagnostic sensitivity of early tomographic fusion imaging.